P.104 Grade 3 meningioma survival, recurrence and functional outcomes in an international multicenter cohort

Background: Meningiomas are the most common intracranial tumor, graded from 1 (benign) to 3 (malignant). The aim of this study was identify clinical features associated with overall survival (OS), progression-free (PFS) and functional status for malignant meningiomas. Methods: Demographic, histopathological data grade meningioma cases were identified in databases seven sites North America Europe 1991-2022. Summary statistics Kaplan-Meier OS PFS curves generated. Results: We 108 patients, a median age 65 years (IQR: 52, 72) 53.7% female. Median 109 months (95% CIs: 88, 227), 5-year rate 65% 56, 76). 38 24, 56) 37% 28, 49). significantly lower patients aged ≥65 years. preoperative KPS score 80 70, 90), postoperatively 90 98) 1-year follow-up 70 50, 80). Conclusions: This provides robust survival, recurrence meningiomas over 30-year period.