P1.02-003 Prevention of Adriamycin-induced Cardiac Damage by NAD-Modulation Prevention of Adriamycin-induced Cardiac Damage by NAD-Modulation
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چکیده
منابع مشابه
Reduction by caffeine of adriamycin-induced cell killing and DNA damage in Chinese hamster cells: correlation with modulation in intracellular adriamycin content.
The effect of caffeine, at concentrations between 10 microM and 20 mM was studied on Adriamycin-induced cytotoxicity and DNA damage in exponentially growing Chinese hamster V79 cells. Simultaneous administration of caffeine with 0.4 micrograms/ml (0.69 microM) Adriamycin for 1 h resulted in a concentration-dependent reduction in cell killing. The surviving fraction increased from 0.001 for cell...
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Colorectal cancer (CRC) is a common malignancy and significant cause of mortality in Western societies. It develops through an accumulation of genetic and epigenetic alterations, transforming normal colon cells and giving them growth advantage. Epigenetic alterations are reversible and studies have shown that dietary compounds can alter the epigenetic status and reactivate epigenetically-silenc...
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We report alkaline elution experiments that reveal the temperature dependence of DNA lesions, both single-strand breaks and DNA-protein cross-links, in L1210 cells exposed to Adriamycin. DNA damage, which at 37 degrees C is equivalent to several hundred rads of ionizing radiation exposure, diminishes as the temperature of drug exposure is lowered. At all temperatures below about 15 degrees C no...
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Adriamycin (ADR) is a potent anticancer drug known to cause severe cardiac toxicity. Although ADR generates free radicals, the role of free radicals in the development of cardiac toxicity and the intracellular target for ADR-induced cardiac toxicity are still not well understood. We produced three transgenic mice lines expressing increased levels of human manganese superoxide dismutase (MnSOD),...
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Certain products of tryptophan metabolism interact with excitatory amino acid receptors to produce or protect against excitotoxicity. In this study, the action of several tryptophan metabolites, yielded by the kynurenine pathway, on cortical cholinergic toxicity was evaluated following focal injection into the rat nucleus basalis magnocellularis (nbM). Metabolites were injected singly or in com...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2017
ISSN: 1556-0864
DOI: 10.1016/j.jtho.2017.09.735