P1-118: Association of Low-Frequency and Rare Coding Variants with Information Processing Speed
نویسندگان
چکیده
منابع مشابه
Rare and low-frequency coding variants alter human adult height
Human height is a highly heritable, polygenic trait1,2. The contribution of common DNA sequence variation to inter-individual differences in adult height has been systematically evaluated through genome-wide association studies (GWAS). This approach has thus far identified 697 independent variants located within 423 loci that together explain around 20% of the heritability of height3. As is typ...
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Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants. To determine whether rare or low-frequency coding variants are associated with LDL-C, we exome sequ...
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Genome-wide association studies (GWASs) have identified loci contributing to total serum bilirubin level. However, no exome-wide approaches have been performed to address this question. Using exome-wide approach, we assessed the influence of protein-coding variants on unconjugated, conjugated, and total serum bilirubin levels in a well-characterized cohort of 773 ambulatory elderly subjects fro...
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................................................................................................................................................................... xi Chapter 1: Introduction ...................................................................................................................................... 1 Chapter 2: Recommended joint and meta-analysis strategies for case-co...
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Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants with larger effects. The aim of this study was to identify low-frequency (minor ...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2016
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2016.06.866