P01 Antibiotic efficacy treatment of community-acquired pneumonia among CMV-infected individuals
نویسندگان
چکیده
Abstract Background The investigation is devoted to possible antibiotic resistance formation and its adverse event prognostic influence among young patients with community-acquired pneumonia (CAP) cytomegalovirus (CMV) persistence absence of other comorbid pathology. Subjects methods observation included 105 (average age 34.1 ± 0.8 years), which had been examined by epidemiological, clinical (including PORT scale) according European Respiratory Society requirements, serological test for CMV IgM, IgG detection usage questionnaire a 3-month period prior CAP. Results 76.2% (n = 80) CAP positive IgG. CMV-positive were characterized higher severity outcome risk in the nearest future versus CMV-negative ones (P < 0.0001): third class—14.9 times higher, fourth class—10.5 higher. IgG–positive results correlated level (r (Spearman) 0.472). In total, 51.4% 54, them 47 patients) mentioned use during last 3 months During treatment, 75.0% 60) 20.0% 5) did not respond treatment cephalosporin quinolone lines needed changes aetiology prescription susceptibility microbial test. 61.3% 47) (everybody was after medication replacement) got events like antibiotic-associated diarrhoea (16 cases), QT prolongation ECG (17 creatinine, urea elevation (11 cases) alanine/aminotransferase (5 cases). Conclusions associated severe without pathologies contributes creation as well related side effects.
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ژورنال
عنوان ژورنال: JAC-antimicrobial resistance
سال: 2023
ISSN: ['2632-1823']
DOI: https://doi.org/10.1093/jacamr/dlad066.005