P-P41 Systematic review of Sarcopenia in Chronic Pancreatitis: prevalence, impact on surgical outcomes and survival

Abstract Background Chronic pancreatitis(CP) is characterised by progressive inflammatory changes to the pancreas, leading loss of endocrine and exocrine function. Emerging literature suggests sarcopenia may adversely affect outcomes for chronic pancreatitis patients. This systematic review examines evidence surrounding impact on patients with CP. Methods A search PUBMED, MEDLINE EMBASE databases identified articles describing body composition assessment in Data collected included definitions sarcopenia, methodology, baseline demographics, surgery related data short- long-term outcomes. Results 9 studies, including 977 a prevalence 32.3% were included. Alcohol was predominant aetiology. There significant heterogeneity used. CT main modality assess 7 papers, MRI 2 papers clinical measurements papers. undergoing total pancreatectomy Islet cell transplantation. None studies found increase complications sarcopenia. 1 Year mortality outpatients from one study CP 16% sarcopenic versus 3% (HR:6.69(95%CI:1.79–24.9),p<0.001). Conclusions Sarcopenia prevalent has adverse survival.