P-754 Chronic poor healing wounds of post cesarean scar diverticulum: altered angiogenesis and immunobiology

Abstract Study question To detect the influences of cesarean section scar diverticula (CSD) on pregnancy outcomes in ART and explore mechanisms. Summary answer In CSD group, cumulative live birth rate （CLBR） was significantly reduced, accompanied by excessive proliferation fibroblasts expansion vascular proliferation. What is known already Diverticulum can reduce chances embryo implantation may lead to spontaneous miscarriages if close or CSD. The accumulation bloody fluid be detected approximately 42% women with large trapped blood slowly released could affect cervical mucus, sperm transport, implantation. previously data have revealed that disrupted uterus microbiota closely associated local inflammatory cytokines which also a clue for impaired fecundity design, size, duration This retrospective cohort study conducted using from single, university-affiliated fertility center. Data analyzed among underwent procedure May 2010 March 2021. Follow-up basic experiments relevant Participants/materials, setting, methods 31375 Sixth affiliated Hospital Sun Yat-sen University. optimize precision study, patients group NCS were matched propensity score matching method. Perform hysteroscopy obtain swab endometrial tissue lower segment. difference uterine cavity environment between vaginal (VB) histopathological immunological analysis. Main results role chance CS had CLBR compared group. Histopathological analysis showed higher prevalent chronic endometritis fibroblast at segment exaggerated situ. Intrauterine including IL-1α, IL-1β, IL-6, IL-8, TNF-α SDF-1α increased Limitations, reasons caution main limitation our its nature single center, might underestimated total number bias. Wider implications findings Lay emphasis anti-infective therapy, modulate imbalance reproductive tract flora enhance early lesion healing post-operation are great necessity. Future studies exploring preventive therapeutic strategies should focus immune response angiogenesis. Trial registration Not applicable