P-645 standard- and low-dose dual trigger compared with human chorionic gonadotropin trigger in preimplantation genetic testing cycles

Abstract Study question Standard-dose dual trigger (SDT) and low-dose (LDT) could improve the number of oocytes, blastocysts euploid or not compared with hCG trigger. Summary answer LDT increased oocytes but among high ovarian responders, while SDT cannot help poor to normal responders. What is known already For low was recommended by ESHRE guidelines for stimulation in vitro fertilization (IVF) /intracytoplasmic sperm injection (ICSI) 2020. this guideline gonadotropin-releasing hormone agonist (GnRH-a) as first-choice treatment. While recent studies showed that increase achieve equivalent better pregnancy outcomes And designed prevent severe hyperstimulation syndrome (OHSS) guaranteeing embryo quality responders previous studies. design, size, duration This retrospective cohort study performed at Center Reproductive Medicine, Department Obstetrics Gynecology, Peking University Third Hospital from July 2018 December 2021. A total 2,649 IVF-PGT cycles involving 2,275 patients were analyzed, which 2,270 had complete baseline data. 1,131, 715, 424 included trigger, SDT, groups, respectively. Participants/materials, setting, methods Patients who triggered SDT(triptorelin acetate 0.2 mg rhCG 250 µg), LDT(triptorelin 125 µg 2,000 IU), (rhCG µg) GnRH-antagonist protocol enrolled. The retrieved, blastocysts, primary endpoints. Propensity score matching (PSM) used control confounding factors study. Main results role chance groups a comparable retrieved (11.0 [7.0, 16.0] vs. 11.0 15.0], p = 0.580), (2.0 [1.0, 3.0] 2.0 3.0], 0.517), (1.0 [0.0, 2.0] 1.0 2.0], 0.383) after PSM. (19.0 [14.0, 25.0] 16.0 [12.0, 21.0], < 0.001) (3.0 [2.0, 6.0] 3.0 5.0], 0.001), 0.111), Limitations, reasons caution single-center characteristics differed those group because clinical decision preferences. PSM these effects generate balanced cohort. Pregnancy transfer has been assessed yet. Wider implications findings change curve induced more similar natural cycle. Probably also benefit IVF/ICSI cycles. might fresh its advantage on endometrial receptivity. Trial registration National Natural Science Foundation China (Grant No.82171626)