P-583 Is donor age a major factor in egg donation for clinical outcome?

Abstract Study question How significant is the age factor for clinical success of controlled ovarian stimulation cycles (COS) in various subgroups egg donors? Summary answer There no negative impact donor outcome donation cycle. What known already It was shown that an independent outcomes, which could predict over 80% IVF success. also reported there were associations between oocyte harvest and probability live birth, adjusting age. Different studies showed less than 25 years old doesn’t better embryo development or pregnancy same group recipients. design, size, duration Three centers having been involved this study, data used from donors (n = 6319) examined 2019-2022, they divided into 3 groups (A: 19-22, B: 23-29, C: ≥30 years). COS protocols analyzed including different parameters: number oocytes retrieved, antral follicle count (AFC), maturation rate (MR), utilization (UR) follicle-to-oocyte index (FOI). The association cycle parameters characteristics assessed by T-Student (parametric) U-Mann-Whitney (non-parametric). Participants/materials, setting, methods In A mean 19-22 , B 23-29 C - 30 717, 1000, 1000 respectively analysed such as: Main results role chance Mean groups: 717) 21,0±1,1; 1000) 26,3±1,9 31,6±1,5. (SD) harvested: 26,94 (12,40), 25,98 (12,03) 23,22 (11,49) A, respectively. tendency with statistical difference observed values AFC: 33,24 (14,55), 32,41 (13,86) 29,77 (12,98). Values FOI higher 81,85 (17,37), 81,06 (18,54) 78,24 (17,97) C, statistically proven (p <0.05) both. MR (83±15%) vs (80±16%) (81±16%) significance <0.05). Recipients (average 33,05) received 94,55% FR, 66,15% BR % 57,84 CPR. Group recipients (age average 35,08) 92,88% 61,69 54,77% ( 33,07) 60,01% 59,05% Limitations, reasons caution This study limited its retrospective nature more are necessary to investigate not only outcomes but related factors on rates. Wider implications findings Our may bring a controversial spotlight doubtful issue relationship programs. Trial registration applicable