P-452 Economic impact of antagonist stimulation protocol vs progestin primed stimulation protocol in oocyte donor program A retrospective study

Abstract Study question Is the cost per oocyte lower in antagonist ovarian stimulation protocol vs progestin primed donation program? Summary answer The is program What known already 1. use of progesterone during effective blocking LH surge, and it does not affect number oocytes collected or quality embryos obtained. Progestins can be used orally are less expensive than GnRH analogues. These new regimens enable more flexibility interesting but their medical economic significance remains to demonstrated. design, size, duration Calculation cost-effectiveness ratios (cost mature achieved) using data derived from retrospective clinical practice a large egg donor single University Hospital between 2011 2021 5677 cycles identified electronic records database were eligible. Participants/materials, setting, methods Donors fulfilled national legal medical-guide requirements, 18- 35 y.o, regular menstrual cycles, BMI 18-30 Kg/m2, no relevant history normal karyotype. They divided into 2 groups(4subgroups): Antagonist FSH group(subcategory recombinant biosimilar FSH) Progestin FSHstimulation FSH). Demographic compared groups. unit gonadotrophin, was calculated according manufacturer’s sale price. Main results role chance mean age women recruited study 26,5 years. distribution different groups as follows: 1.1. 3155 (55,6%) antagonists group (FSHrA), Mean days 9,17-antagonists 4,91; eggs:13,62 2.2. 1489 (26,2%) (FSHrbA), days: 5,28; eggs: 13,37 3.3. 187 (3%) (FSHrPP), 9,26-desogestrel 23; 12,54 4.4. 846 (14,9%) group(FSHrbPP). 9,07-desogestrel 24; 13,78 According outcomes donor, we did find statistical differences neither nor eggs each treatment there higher rate range 0-4 group. costs for drug 0,33-0,382€ FSH; 0,299-0,33€ 25,85€ Ganirelix; 0,14 Desogestrel. In conclusion, savings achieved treatment. 52,59€ with 58,25€ Limitations, reasons caution Cancellations before reaching pickup contemplated,they may increase total cycle. Although equivalent groups, visits including nursing, infrastructure, patient care time consumables might Wider implications findings present an option programs terms Trial registration applicable