P-3 Gastric cancer: 10-year survival

10-Year survival (10YS) after radical surgery for gastric cancer (GC) patients (GCP) (T1-4N0-2M0) was analyzed. We analyzed data of 796 consecutive GCP (age=57.1±9.4 years; tumor size=5.4±3.1 cm) radically operated (R0) and monitored in 1975-2021 (m=556, f=240; distal gastrectomies-G=461, proximal G=165, total G=170, D2 lymph node dissection=551; combined G with resection 1-7 adjacent organs (pancreas, liver, diaphragm, esophagus, colon transversum, splenectomy, small intestine, kidney, adrenal gland, etc.)=245; D3-4 dissection=245; only surgery-S=623, adjuvant chemoimmunotherapy-AT=173: 5FU+thymalin/taktivin; T1=237, T2=220, T3=182, T4=157; N0=435, N1=109, N2=252, M0=796; G1=222, G2=164, G3=410; early GC=164, invasive GC=632; Variables selected 10YS study were input levels 45 blood parameters, sex, age, TNMG, cell type, size. Survival curves estimated by the Kaplan-Meier method. Differences between groups evaluated using a log-rank test. Multivariate Cox modeling, discriminant analysis, clustering, SEPATH, Monte Carlo, bootstrap neural networks computing used to determine any significant dependence. Overall life span (LS) 2130.8±2304.3 days cumulative 5-year (5YS) reached 58.4%, 10 years – 52.4%, 20 40.4%. 316 lived more than 5 (LS=4316.1±2292.9 days), 169 (LS=5919.5±2020 days). 294 died because GC (LS=640.6±347.1 AT significantly improved (62.3% vs. 50.5%) (P=0.0228 test) GCP. modeling displayed that LCP depended on: phase transition (PT) early-invasive terms synergetics, PT N0—N12, ratio factors (ratio cells- CC cells subpopulations), G1-3, AT, circuit, prothrombin index, hemorrhage time, residual nitrogen, procedure type (P=0.000-0.039). Neural networks, genetic algorithm selection simulation revealed relationships healthy cells/CC (rank=1), (rank=2), N0—N12(rank=3), erythrocytes/CC (4), thrombocytes/CC (5), monocytes/CC (6), segmented neutrophils/CC (7), eosinophils/CC (8), leucocytes/CC (9), lymphocytes/CC (10), stick (11). Correct prediction 5YS 100% (area under ROC curve=1.0; error=0.0). procedures 1) cancer; 2) N0--N12; 3) factors; 4) circuit; 5) biochemical 6) hemostasis system; 7) AT; 8) characteristics; 9) anthropometric data; 10) type. Optimal diagnosis treatment strategies LC are: screening detection GC; availability experienced abdominal surgeons complexity procedures; aggressive en block adequate dissection completeness; precise prediction; chemoimmunotherapy unfavorable prognosis.