P-033 Impact of the sperm reactive oxygen species on Intrauterine Insemination outcome

Abstract Study question Does sperm reactive oxygen species values affect the pregnancy rate after Intrauterine Insemination (IUI)? Summary answer Sperm and can be used as a predictive marker for IUI outcome. What is known already Oxidative stress resulting from excessive production of (ROS) profoundly subsequent functional integrity. Diagnostics to measure semen oxidative have been added 6th edition WHO laboratory manual examining processing human semen, under advanced examinations. Although analysis has classically gold standard determining man’s fertility, basic alone cannot accurately predict infertility since between 6 27 % men with normal parameters are infertile. Determination in diagnosing may contribute better outcomes. design, size, duration This study was based on analyses 50 male patients whose samples were treatment November 2022 January 2023. The oxidation-reduction potential measured using novel galvanostat-based technology, MiOXSYS System. Briefly, 30 μL liquefied at room temperature applied sensor. Both absolute ORP (mV) normalized sORP ( mV/10 sperm/ml) concentration calculated. Participants/materials, setting, methods performed according criteria (Sixth 2021). All participants followed period 3–5 days sexual abstinence had diagnosis unexplained (normozoospermia). Ovarian stimulation cycle initiated 5th day menstruation by recombinant gonadotropins. Clinical determined Beta-hCG values. For statistical comparison group Mann-Whitney U test used. Main results role chance According guidelines World Health Organization, all included BMI (21.85±3.80 kg/m2). average age female 33.9 ± 3.1 years while 37.8 4.8 years. Out patients, 32% (N = 16) got pregnant. propose compared Statistical showed significant difference Patients positive outcome lower value where not successful [25.65 [6.7-52.6] mV vs. 40.2 [6.3-109.8] mV, respectively, p 0.02]. Additionally, (sORP) also significantly different those groups [ 0.37(0.17-1.44) sperm/ml 0.88(0.13-20.81) sperm/ml, respectively 0.006]. Due above-mentioned logistic regression performed, obtained confirm that (p 0.02) well 0.016) affects procedure. Limitations, reasons caution limitation presented relatively small patient cohort. beta hCG values, therefore future research should link live birth well. Wider implications findings In present suggests an additional parameter diagnostic identify best therapeutic approach concerning couples show minimal or no impairments parameter. Trial registration number applicable