P-007. Prostasomes inhibit NADPH-oxidase activity of human polymorphonuclear neutrophils
نویسندگان
چکیده
منابع مشابه
Prostasomes inhibit the NADPH oxidase activity of human neutrophils.
Prostasomes are particular lipid vesicles secreted by the prostate in human semen and involved in several physiological functions such as the improvement of sperm motility or immunomodulation. We have previously shown that they reduced the overall reactive oxygen species (ROS) production of seminal polymorphonuclear neutrophils (PMN). The present study was conducted to define the mechanism by w...
متن کاملFurther characterization of NADPH oxidase activity of human polymorphonuclear leukocytes.
Mn2+ was shown to catalyze a nonenzymatic oxidation of NADPH in the presence of superoxide anion by means of an isotopic assay for measurement of the oxidation of NADPH to NADP+. Human polymorphonuclear leukocyte granule NADPH oxidase activity was evaluated in the absence of Mn2+ and was found to be higher in granules from phagocytizing cells than in granules from resting cells. The drug phorbo...
متن کاملBacillus anthracis toxins inhibit human neutrophil NADPH oxidase activity.
Bacillus anthracis, the causative agent of anthrax, is a Gram-positive, spore-forming bacterium. B. anthracis virulence is ascribed mainly to a secreted tripartite AB-type toxin composed of three proteins designated protective Ag (PA), lethal factor, and edema factor. PA assembles with the enzymatic portions of the toxin, the metalloprotease lethal factor, and/or the adenylate cyclase edema fac...
متن کاملP-21 activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils Pak regulates phagocyte NADPH oxidase
P-21 activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils Pak regulates phagocyte NADPH oxidase Kendra D. Martyn, Moon-Ju Kim, Mark T. Quinn, Mary C. Dinauer and Ulla G. Knaus These authors contributed equally to this work Dr. Martyn and Dr. Kim performed research Dr. Quinn and Dr. Dinauer contributions are essential reagents and manuscript revision Dr. Knaus designed ...
متن کاملGuanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils.
In the chain of events by which chemotactic peptides stimulate NADPH oxidase-catalyzed superoxide formation in human neutrophils, the involvements of a pertussis toxin-sensitive guanine nucleotide-binding protein (N-protein), mobilization of intracellular calcium and protein kinase C stimulation have been proposed. Superoxide formation was studied in membranes from human neutrophils; NADPH oxid...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Human Reproduction
سال: 1999
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/14.suppl_3.142-a