P-004 Sperm concentration of less than 1 million/ml in Y microdeletion patients may affect ICSI clinical outcomes: a propensity score matching analysis

Abstract Study question To investigate which semen parameter in AZFc microdeletion patients affect the intracytoplasmic sperm injection (ICSI) clinical outcomes. Summary answer AZF-microdeletion caused oligospermia affected ICSI outcome when concentration is less than 1x106/ml. What known already reduce impact of female factors on outcomes, this study employed a propensity score matching analysis to retrospectively analyze laboratory and pregnancy results with deletion who underwent ICSI. design, size, duration A retrospective cohort 99 198 without microdeletion. Participants/materials, setting, methods Patients/Animals: or undergoing Intervention: for couples attempting conception. Main Outcome Measures: Outcomes included normal fertilization rate, high-quality embryo rate Day 3, abortion live birth rate. role chance Patients had lower (69.55%) Day-3 (50.73%) control group (77.17% 58.44% respectively, p = 0.000). There was no significant difference between two groups (67.21% vs. 68.16%, > 0.05), miscarriage (13.41% 12.54%, (58.20% 59.18%, 0.05). Subgroup showed that were comparable AZFc-microdeletion 106/ml. Interestingly, below 1x106/ml, (65.60% 73.79%, 0.001) (47.74% 58.48%, significantly those group. Furthermore, lower, while higher group; however, statistical not significant. Limitations, reasons caution limited, cases obtaining testicular by microsurgery included, so may be biased, prospective studies larger sample size need designed further confirmation. Wider implications findings We recommend screening AZF Chinese male infertile population 5X106/ml.The physician should advise patient undergo genetic counseling before assistance, choose whether PGT assisted according patient's wishes. Trial registration number applicable