منابع مشابه
Oxytocin Signaling in Mouse Taste Buds
BACKGROUND The neuropeptide, oxytocin (OXT), acts on brain circuits to inhibit food intake. Mutant mice lacking OXT (OXT knockout) overconsume salty and sweet (i.e. sucrose, saccharin) solutions. We asked if OXT might also act on taste buds via its receptor, OXTR. METHODOLOGY/PRINCIPAL FINDINGS Using RT-PCR, we detected the expression of OXTR in taste buds throughout the oral cavity, but not ...
متن کاملShh signaling and regulatory gene expression in mouse taste buds.
In mammals, taste buds arise from local epithelium and are maintained by continuous cell renewal (Beidler and Smallman, 1965; Farbman, 1980; Delay et al., 1986; Stone et al., 1995). The life span of taste cells is estimated to be ~10 days. Denervation causes the degeneration of taste buds, indicating that the taste nerves trophically maintain the taste buds. It is assumed that cell proliferatio...
متن کاملMouse taste buds release serotonin in response to taste stimuli.
Cell-to-cell interactions and synaptic integration may occur within taste buds prior to signals being exported from these peripheral sensory organs to the CNS (Roper, 1992; Kaya et al., 2004). In principle, these interactions could include chemical and electrical synapses between taste cells and synapses from taste cells to sensory afferent fibers. Knowing which transmitters are released at syn...
متن کاملVismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds
Vismodegib, a highly selective inhibitor of hedgehog (Hh) pathway, is an approved treatment for basal-cell carcinoma. Patients on treatment with vismodegib often report profound alterations in taste sensation. The cellular mechanisms underlying the alterations have not been studied. Sonic Hh (Shh) signaling is required for cell growth and differentiation. In taste buds, Shh is exclusively expre...
متن کاملNorepinephrine is coreleased with serotonin in mouse taste buds.
ATP and serotonin (5-HT) are neurotransmitters secreted from taste bud receptor (type II) and presynaptic (type III) cells, respectively. Norepinephrine (NE) has also been proposed to be a neurotransmitter or paracrine hormone in taste buds. Yet, to date, the specific stimulus for NE release in taste buds is not well understood, and the identity of the taste cells that secrete NE is not known. ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0011980