Oxytocin in rat nucleus raphe magnus influences pain modulation
نویسندگان
چکیده
منابع مشابه
Oxytocin in rat nucleus raphe magnus influences pain modulation
The main function of Nucleus raphe magnus (NRM) is mostly pain mediation. Our previous study has demonstrated that oxytocin (OXT) regulates antinociception through the central nervous system rather than the peripheral organs, and pain stimulation increases OXT concentration in the NRM. The experiment was designed to investigate OXT in the rat NRM effect on pain modulation. The results showed th...
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Purpose: The nucleus raphe magnus (NRM) is a medullary nucleus containing serotonergic and non serotonergic neurons, both of which densely project to spinal cord. The goal of this study was to determine the role of these non serotonergic neurons in pain perception and their cytological changes after the specific lesion of bulbo-spinal serotonergic pathway. Materials and Methods: Male rats were...
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Introduction: The antinociceptive effect of morphine is, in part, mediated through the activation of a descending pathway. One of the major components of this pathway is the nucleus raphe magnus (NRM). Our previous study demonstrated the involvement of NRM in the analgesic effect of morphine microinjected into the nucleus cuneiformis (NCF) in a descending manner. The aim of the current study...
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The present study demonstrated that 5-HT receptor mRNA was expressed with moderate level in the NRM neurons. Most of 5-HT 1A 1A receptor mRNA positive cells were 5-HT neurons, suggesting the majority of 5-HT receptor in the NRM might be autoreceptors. Eight 1A hours after carrageenan inflammation, the expression of 5-HT receptor mRNA in the NRM neurons, especially in the 5-HT neurons, 1A was si...
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ژورنال
عنوان ژورنال: World Journal of Neuroscience
سال: 2012
ISSN: 2162-2000,2162-2019
DOI: 10.4236/wjns.2012.22017