Oxyntomodulin regulates resetting of the liver circadian clock by food

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Oxyntomodulin regulates resetting of the liver circadian clock by food

Circadian clocks coordinate 24-hr rhythms of behavior and physiology. In mammals, a master clock residing in the suprachiasmatic nucleus (SCN) is reset by the light-dark cycle, while timed food intake is a potent synchronizer of peripheral clocks such as the liver. Alterations in food intake rhythms can uncouple peripheral clocks from the SCN, resulting in internal desynchrony, which promotes o...

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Title : Oxyntomodulin regulates resetting of the liver circadian clock

1 Contributed equally 5 2 Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Göttingen, 6 Germany. 7 3 Chronophysiology Group, Medical Department I, University of Lübeck, Lübeck, Germany. 8 4 Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 9 University of Toronto, Toronto, Ontario, Canada. 10 5 Current address: Department of Psychiatry...

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Rapid resetting of the mammalian circadian clock.

The suprachiasmatic nuclei (SCN) contain the principal circadian clock governing overt daily rhythms of physiology and behavior. The endogenous circadian cycle is entrained to the light/dark via direct glutamatergic retinal afferents to the SCN. To understand the molecular basis of entrainment, it is first necessary to define how rapidly the clock is reset by a light pulse. We used a two-pulse ...

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Phase Resetting of the Mammalian Circadian Clock by DNA Damage

To anticipate the momentum of the day, most organisms have developed an internal clock that drives circadian rhythms in metabolism, physiology, and behavior [1]. Recent studies indicate that cell-cycle progression and DNA-damage-response pathways are under circadian control [2-4]. Because circadian output processes can feed back into the clock, we investigated whether DNA damage affects the mam...

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Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock.

The transcription factor CLOCK-BMAL1 is a core component of the molecular clock machinery that drives circadian gene expression and physiology in mammals. Recently, we reported that this heterodimeric transcription factor functions as a signaling molecule in response to the resetting stimuli via the Ca²+-dependent protein kinase C pathway. Here, we demonstrate that the CREB-binding protein (CBP...

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ژورنال

عنوان ژورنال: eLife

سال: 2015

ISSN: 2050-084X

DOI: 10.7554/elife.06253