Oxyntomodulin Inhibits Food Intake in the Rat
نویسندگان
چکیده
منابع مشابه
Increased food intake with oxyntomodulin analogues
Oxyntomodulin analogues offer a novel treatment for obesity. However during analogue screening in a rat model increased food intake was consistently observed. To further investigate this finding, a series of representative analogues (OXM14 and OXM15) and their Glu-3 equivalents (OXM14E3 and OXM15E3) were administered to rats for 7 days and food intake and bodyweight measurements taken. To inves...
متن کاملCentral effect of mammalian oxyntomodulin on food intake in non-fasted and fasted chicks
Oxyntomodulin (OXM), a proglucagon-derived peptide, is a well known anorexigenic peptide found inthe gut and brain of mammals. The present study was carried out to investigate the central effect of OXM onfood intake in non-fasted and fasted Ross broiler chicks. At four weeks of age, a guide cannula wasstereotaxically implanted into the right lateral ventricle of each bird. Two experiments were ...
متن کاملPeripheral oxyntomodulin reduces food intake and body weight gain in rats.
Oxyntomodulin (OXM) is a circulating gut hormone released post prandially from cells of the gastrointestinal mucosa. Given intracerebroventricularly to rats, it inhibits food intake and promotes weight loss. Here we report that peripheral (ip) administration of OXM dose-dependently inhibited both fast-induced and dark-phase food intake without delaying gastric emptying. Peripheral OXM administr...
متن کاملcentral effect of mammalian oxyntomodulin on food intake in non-fasted and fasted chicks
oxyntomodulin (oxm), a proglucagon-derived peptide, is a well known anorexigenic peptide found inthe gut and brain of mammals. the present study was carried out to investigate the central effect of oxm onfood intake in non-fasted and fasted ross broiler chicks. at four weeks of age, a guide cannula wasstereotaxically implanted into the right lateral ventricle of each bird. two experiments were ...
متن کاملOxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure.
BACKGROUND & AIMS Gut-derived peptides including ghrelin, cholecystokinin (CCK), peptide YY (PYY), glucagon-like peptide (GLP-1), and GLP-2 exert overlapping actions on energy homeostasis through defined G-protein-coupled receptors (GPCRs). The proglucagon-derived peptide (PGDP) oxyntomodulin (OXM) is cosecreted with GLP-1 and inhibits feeding in rodents and humans; however, a distinct receptor...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2001
ISSN: 0013-7227
DOI: 10.1210/en.142.10.4244