Oxygen, oxidative stress, hypoxia, and heart failure
نویسندگان
چکیده
منابع مشابه
Oxygen, oxidative stress, hypoxia, and heart failure.
A constant supply of oxygen is indispensable for cardiac viability and function. However, the role of oxygen and oxygen-associated processes in the heart is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death. As oxygen is a major determinant of cardiac gene expression, and a critical participant in the formation of ROS and numerous other cellular proce...
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There is growing evidence that oxidative stress is increased in myocardial failure and may contribute to the structural and functional changes that lead to disease progression. The report by Ide et al,1 in this issue of Circulation Research, provides the first direct measurement of increased oxidative stress in the myocardium of an animal model of heart failure. In this same model, the authors ...
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Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative to antioxidant defense, has been shown to play an important role in the pathophysiology of cardiac remodeling and heart failure (HF). It induces subtle changes in intracellular pathways, redox signaling, at lower levels, but causes cellular dysfunction and damage at higher levels. ROS are derived from se...
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Oxidative stress is one of the new and most intriguing pathogenetic hypotheses of heart failure; it involves various mechanisms such as endothelial dysfunction, mechano-energetic uncoupling and apoptosis. Xanthine oxidase, a key enzyme in purine catabolism, is overexpressed in patients with heart failure, and it is also an important source of oxidizing activity molecules (free radicals, superox...
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Oxidative stress contributes to various cardiovascular diseases and aging and was causally linked to the progression of heart failure (1,2). Among the most relevant sources for reactive oxygen species (ROS) are nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and mitochondria (1,3–7). The ROS impair excitation-contraction coupling, cause arrhythmias, and contribute to cardiac remode...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2005
ISSN: 0021-9738
DOI: 10.1172/jci200524408