Oxygen dependence of vitamin K-dependent carboxylase and vitamin K epoxidase
نویسندگان
چکیده
منابع مشابه
The vitamin K-dependent carboxylase.
The only known biological function of Vitamin K (Fig. 1) in animals is as a required cofactor for the production of the unusual amino acid, -carboxyglutamate (Gla). This amino acid has a profound role in human blood coagulation. Several blood proteins require the presence of nine to thirteen Gla residues for normal function; these are the socalled Vitamin K-dependent (VKD) proteins. While some ...
متن کاملVitamin K-dependent carboxylation of the carboxylase.
Vitamin K-dependent (VKD) proteins require modification by the VKD-gamma-glutamyl carboxylase, an enzyme that converts clusters of glus to glas in a reaction that requires vitamin K hydroquinone, for their activity. We have discovered that the carboxylase also carboxylates itself in a reaction dependent on vitamin K. When pure human recombinant carboxylase was incubated in vitro with 14CO2 and ...
متن کاملA case report of temporary and acquired vitamin K-dependent clotting factor deficiency without any response to administrated vitamin K
Abstract Background and Objectives Vitamin K-dependent clotting factor deficiency (VKCFD) is usually an acquired problem due to liver disease, malabsorption, and overdose of warfarin. In the present paper the significance and role of vitamin K-dependent coagulation factors in menorrhagia were evaluated. Case We present a rare case of 43 year woman with acquired vitamin K deficiency and se...
متن کاملy-Carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase
Vitamin K functions as a cofactor during the posttranslational modification of proteins. The reaction in question is the carboxylation of glutamate (Glu) residues into y-carboxyglutamate (Gla) and it is depicted in Fig. 1. Because Glu is only a weak Ca2l chelator and Gla a much stronger one, the vitamin K-dependent step substantially increases the Ca2"-binding capacity ofa protein. The discover...
متن کاملPropeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state.
The vitamin K-dependent gamma-glutamyl carboxylase catalyzes the posttranslational conversion of glutamic acid to gamma-carboxyglutamic acid in precursor proteins containing the gamma-carboxylation recognition site (gamma-CRS). During this reaction, glutamic acid is converted to gamma-carboxyglutamic acid while vitamin KH2 is converted to vitamin K 2,3-epoxide. Recombinant bovine carboxylase wa...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1986
ISSN: 0014-5793
DOI: 10.1016/0014-5793(86)80513-0