Oxidized LDL Can Promote Human Monocyte Survival
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چکیده
منابع مشابه
PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL
sad et al., 1996), and CD32 (FcgRII; Stanton et al., 1992). The formation of foam cells from macrophages in the While the in vivo relevance of some of these proteins arterial wall is characterized by dramatic changes in remains to bedetermined, recent data support an imporlipid metabolism, including increased expression of tant role for both SR-A and CD36 in the pathogenesis scavenger receptors...
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OBJECTIVE Wnt5a is a secreted glycoprotein highly present in atherosclerotic lesions. Uptake of oxidized-low density lipoprotein (ox-LDL) by monocytes/macrophages plays a critical role in atherosclerosis. The objective of this study was to determine if Wnt5a mRNA expression correlates with the severity of atherosclerotic lesions, and if, ox-LDL can induce Wnt5a mRNA in macrophages. METHODS Wn...
متن کاملOxidized LDL increases and interferon-gamma decreases expression of CD36 in human monocyte-derived macrophages.
CD36 is a glycoprotein with an Mr of 88 kDa that is expressed on platelets, monocytes/macrophages, capillary endothelial cells, and adipocytes. We previously demonstrated that CD36 is involved in the uptake of oxidized low density lipoprotein (OxLDL) by using CD36-deficient macrophages (J Clin Invest. 1995;96:1859). However, the regulation of CD36 expression in human monocyte-derived macrophage...
متن کاملOxidized LDL Increases and Interferon-g Decreases Expression of CD36 in Human Monocyte–Derived Macrophages
CD36 is a glycoprotein with an Mr of 88 kDa that is expressed on platelets, monocytes/macrophages, capillary endothelial cells, and adipocytes. We previously demonstrated that CD36 is involved in the uptake of oxidized low density lipoprotein (OxLDL) by using CD36-deficient macrophages (J Clin Invest. 1995;96:1859). However, the regulation of CD36 expression in human monocyte–derived macrophage...
متن کاملOxidized LDL-mediated macrophage survival involves elongation factor-2 kinase.
OBJECTIVE Macrophage survival and proliferation is believed to be a contributing factor in the development of early atherosclerotic lesions. Oxidized low density lipoprotein (oxLDL), a key mediator in the pathogenesis of this disease, has been shown to block apoptosis in macrophages deprived of growth factor. In this report, we investigate the mechanism of oxLDL-mediated macrophage survival. ...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2000
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.20.10.2329-a