Oxidative stress-triggered nuclear WRAP53 translocation promotes neuronal survival and functional recovery after stroke

Optogenetic neuronal stimulation promotes functional recovery after stroke.

Clinical and research efforts have focused on promoting functional recovery after stroke. Brain stimulation strategies are particularly promising because they allow direct manipulation of the target area's excitability. However, elucidating the cell type and mechanisms mediating recovery has been difficult because existing stimulation techniques nonspecifically target all cell types near the st...

Sildenafil (Viagra) Induces Neurogenesis and Promotes Functional Recovery After Stroke

Ruilan Zhang, Ying Wang, Li Zhang, Zhenggang Zhang, Wayne Tsang, Mei Lu, Lijie Zhang in Rats Sildenafil (Viagra) Induces Neurogenesis and Promotes Functional Recovery After Stroke Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi:...

Optogenetic neuronal stimulation of the lateral cerebellar nucleus promotes persistent functional recovery after stroke

Stroke induces network-wide changes in the brain, affecting the excitability in both nearby and remotely connected regions. Brain stimulation is a promising neurorestorative technique that has been shown to improve stroke recovery by altering neuronal activity of the target area. However, it is unclear whether the beneficial effect of stimulation is a result of neuronal or non-neuronal activati...

Nuclear Translocation of Components of the Neuronal Plasma Membrane Oxidoreductase after Oxidative Stress and its Effects on Induction of Apoptosis

Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage.

Tyrosyl-tRNA synthetase (TyrRS) is well known for its essential aminoacylation function in protein synthesis. Recently, TyrRS has been shown to translocate to the nucleus and protect against DNA damage due to oxidative stress. However, the mechanism of TyrRS nuclear localization has not yet been determined. Herein, we report that TyrRS becomes highly acetylated in response to oxidative stress, ...