Oxidative stress-induced poly(ADP-ribosyl)ation in chick limb bud-derived chondrocytes
نویسندگان
چکیده
منابع مشابه
Oxidative stress-induced poly(ADP-ribosyl)ation in chick limb bud-derived chondrocytes.
Oxidative stress has been implicated in the pathogenesis of various diseases affecting chondrogenesis or the function of articular cartilage. DNA damage caused by oxidative stress may trigger the activation of the nuclear enzyme, poly(ADP-ribose) polymerase-1 (PARP-1) which may contribute to tissue injury. We aimed at investigating the effects of peroxynitrite (100-600 microM) and hydrogen pero...
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Background: Cyclosporine A (CsA) is a powerful immunosuppressive agent, which is used for the prevention of allograft rejection and for the treatment of autoimmune diseases. Many transplant recipients must take this medicine for the rest of their lives. Females in reproductive age group on prolonged CsA therapy have legitimate concerns about drug effects on pregnancy. Objective: To explore Cs...
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PolyADP-ribosylation is a transient posttranslational modification of proteins, mainly catalyzed by poly(ADP-ribose)polymerase-1 (PARP-1). This highly conserved nuclear protein is activated rapidly in response to DNA nick formation and promotes a fast DNA repair. Here, we examine a possible association between polyADP-ribosylation and the activity of neurotrophins and neuroprotective peptides t...
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The chick limb bud is a powerful experimental system in which to study pattern formation in vertebrate embryos. Exogenously applied retinoic acid, a vitamin A derivative, can bring about changes in pattern and, on several grounds, is a good candidate for an endogenous morphogen. As such, the local concentration of retinoic acid might provide cells with information about their position in relati...
متن کاملcyclosporine effects on chick limb bud mesenchyme and dna content
background: cyclosporine a (csa) is a powerful immunosuppressive agent, which is used for the prevention of allograft rejection and for the treatment of autoimmune diseases. many transplant recipients must take this medicine for the rest of their lives. females in reproductive age group on prolonged csa therapy have legitimate concerns about drug effects on pregnancy. objective: to explore ...
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ژورنال
عنوان ژورنال: International Journal of Molecular Medicine
سال: 2007
ISSN: 1107-3756,1791-244X
DOI: 10.3892/ijmm.19.4.597