Oxidative Stress in the Pathogenesis of Colorectal Cancer: Cause or Consequence?

Oxidative Stress in the Pathogenesis of Colorectal Cancer: Cause or Consequence?

There is a growing support for the concept that reactive oxygen species, which are known to be implicated in a range of diseases, may be important progenitors in carcinogenesis, including colorectal cancer (CRC). CRC is one of the most common cancers worldwide, with the highest incidence rates in western countries. Sporadic human CRC may be attributable to various environmental and lifestyle fa...

Oxidative Stress: Cause and Consequence of Diseases

Oxidative stress, termed as an imbalance between production and elimination of reactive oxygen species (ROS) leading to plural oxidative modifications of basic and regulatory processes, can be caused in different ways. Increased steady-state ROS levels can be promoted by drug metabolism, overexpression of ROS-producing enzymes, or ionizing radiation, as well as due to deficiency of antioxidant ...

Tumor angiogenesis: cause or consequence of cancer?

Both tumors and normal tissues need a blood supply for oxygen, nutrients, and waste removal. However, whereas normal vasculature is hierarchically assembled into efficient networks of arteries, capillaries, and veins, the blood vessels of tumors are a mess-chaotic, leaky, inefficient, and barely making do. Why the difference? Do tumor vessels lack the signals to mature or, instead, is their mat...

Oxidative Stress and Tumor Progression in Colorectal Cancer Running title: Oxidative stress in colorectal cancer

Role of oxidative stress in pathogenesis of metabolic syndrome

The metabolic syndrome (MS) recognized as a major cause of type 2 diabetes and cardiovascular diseases, has become one of the major public health challenges worldwide. The pathogenesis of the metabolic syndrome is multiple and still poorly understood. No single factor has yet been identified as an underlying causal factor. There is a growing belief, however, that obesity, specially visceral obe...