Oxidative stress in pancreatic alpha and beta cells as a selection criterion for biocompatible biomaterials

The clinical success rate of islet transplantation, namely independence from insulin injections, is limited by factors that lead to graft failure, including inflammation, acute ischemia, phase response, and insufficient vascularization. ischemia vascularization both high levels oxidative stress, which are further aggravated encapsulation, undesirable cell-biomaterial interactions. To identify biomaterials would not increase damaging stress also suitable for manufacturing a beta cell encapsulation device, we studied five clinically approved polymers their effect on (alpha cell) function. We found 300 poly(ethylene oxide terephthalate) 55/poly(butylene 45 (PEOT/PBT300) was more resistant breakage elastic than other biomaterials, important its immunoprotective In addition, it did induce or reduce viability in the MIN6 line, even promoted protective endogenous antioxidant expression over 7 days. Importantly, PEOT/PBT300 one interfere with secretion human islets.