Oxidative Stress in Neurodegenerative Diseases

Oxidative Stress in Neurodegenerative Diseases and Ageing

Since Denham Harman has proposed the free radical theory of ageing, the knowledge and the understanding of the mechanisms of ageing process have increased remarkably. Over decades, this unavoidable phenomenon has also been linked, both causatively and consequently, with the development of several abnormalities, currently known as the “agerelated diseases.” Oxidative Medicine and Cellular Longev...

Melatonin oxidative stress and neurodegenerative diseases.

Oxidative Stress is implicated as one of the primary factors that contribute to the development of neurodegenerative diseases like Alzheimer's Disease, Parkinsonism and neurological conditions like epileptic seizures, stroke, brain damage, neurotrauma etc. The increased formation and release of oxygen free radicals coupled with the rather low antioxidative potential of the central nervous syste...

Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases

Cytoplasmic stress granules (SGs) are critical for facilitating stress responses and for preventing the accumulation of misfolded proteins. SGs, however, have been linked to the pathogenesis of neurodegenerative diseases, in part because SGs share many components with neuronal granules. Oxidative stress is one of the conditions that induce SG formation. SGs regulate redox levels, and SG formati...

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases

Oxidative Stress in Neurodegenerative Diseases: Mechanisms and Therapeutic Perspectives

The incidence and prevalence of neurodegenerative diseases (ND) increase with life expectancy. This paper reviews the role of oxidative stress (OS) in ND and pharmacological attempts to fight against reactive oxygen species (ROS)-induced neurodegeneration. Several mechanisms involved in ROS generation in neurodegeneration have been proposed. Recent articles about molecular pathways involved in ...