Oxidative stress and changes in liver sialoglycoconjugate metabolic parameters in rats with alloxanic diabetes mellitus

BACKGROUND : Oxidative stress may be one of the mechanisms for development complications in DM and many forms CKD. However, influence this factor on metabolism sialoglycoconjugates, which actively participates regulatory processes body, is unknown. AIM comparative study effect lipoic acid parameters liver sialoglycoconjugate rats with alloxan diabetes mellitus. MATERIALS AND METHODS Studies were conducted white male weighing 180–220 grams. The animals divided into three groups: first second groups, mellitus (DM) was caused by a single subcutaneous injection tetrahydrate (AT). Animals group received intramuscularly; third consisted intact rats. On 5, 10, 20, 30 40 days after AT, comprehensive examination animal’s condition performed: 1) determination level glycemia; 2) assessment degree oxidative content TBK-active products liver; 3) dynamics exchange sialoglycoconjugates (free, oligo-and protein-bound sialic acids, sialidase activity). RESULTS 106 rats, each experimental had 48 animals, control — 10. It found that administration α-lipoic to leads decrease glycemia. introduction did not reduce activity all fractions liver, although it reduced body. CONCLUSION Supplementation significantly under organism. increased rate alloxan-diabetic indicate restructuring hepatocyte adapt whole organism prolonged hyperglycemia insulin deficiency conditions.