Oxidative DNA cleavage, cytotoxicity and antimicrobial studies of l-ornithine copper (II) complexes
نویسندگان
چکیده
منابع مشابه
DNA binding and oxidative cleavage activity of ternary (L-proline)copper(II) complexes of heterocyclic bases
Ternary copper(II) complexes [Cu(L-pro)(B)(H2O)](NO3) (1, 2) where L-pro = L-proline, B is a N,N-donor heterocyclic base, viz. 2,2 0bipyridine (bpy, 1), 1,10-phenanthroline (phen, 2), are synthesized, characterized, and their DNA binding and cleavage activity studied. The bpy complex (1) is structurally characterized by single-crystal X-ray crystallography. The complexes show the presence of a ...
متن کاملBiologically vital metal-based antimicrobial active mixed ligand complexes: synthesis, characterization, DNA binding and cleavage studies
Few novel cobalt(II) and copper(II) complexes [M(fmp)3]Cl2, [M(fmp)(bpy)2]Cl2,[M(fmp)(phen)2]Cl2 and [M(fmp)(phen)(bpy)]Cl2 (fmp = 3-furan-2-ylmethylene-pentane-2,4-dione, phen = 1,10-phenanthroline, bpy = 2,2'-bipyridine) have been synthesized andcharacterized by elemental analyses, molar conductance, magnetic susceptibility measurements,IR, electronic, EPR, mass spectra and cyclic voltammetri...
متن کاملSpectroscopic evidence of Cu(II) and Zn(II) complexes having amino acid based Schiff base: A special emphasis on in vitro antimicrobial, DNA binding and cleavage studies
A new Schiff base ligand (L) obtained by the condensation reaction of N-acetylaceto-otoluidineand 2-aminopropanoic acid (an amino acid), is used to synthesize four mononuclearcomplexes of [MLCl] and [ML2] types (where M = Cu(II) and Zn(II); L = Schiff base) bykeeping the metal and ligand ratio as 1:1 and 1:2 respectively. This ligand and its complexeshave been characterized on the basis of diff...
متن کاملMetal (II) Complexes of Fluconazole: Thermal, XRD and Cytotoxicity Studies
We report thermal, X-ray diffraction (XRD) and cytotoxicity studies of complexes of fluconazole (FCZ) with Cu (II), Fe(II), Cd(II), Co(II), Ni(II), and Mn(II). From XRD measurements, FCZ and its metal complexes were identified as polycrystalline. Marked differences in the X-ray patterns of drug and its metal complexes revealed that the complexes are indeed different compounds and not just the m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Polyhedron
سال: 2012
ISSN: 0277-5387
DOI: 10.1016/j.poly.2012.08.081