Oxidant-mediated damage of Leishmania donovani promastigotes
نویسندگان
چکیده
منابع مشابه
Surface antigens of Leishmania donovani promastigotes
Surface antigen profiles of Leishmania donovani promastigote isolates have been studied. Surface patterns of Brazilian and African isolates display remarkable similarities and are extremely simple, consisting of three major peptides of 65,000, 25,000, and 23,000 mol wt. Surface iodination and biosynthetic labeling coupled to immunoprecipitation techniques revealed that a single major determinan...
متن کامل1564 Surface Antigens of Leishmania Donovani Promastigotes
Leishmania donovani, the agent of visceral leishmaniasis , is a t r y p a n o s o m a t i d protozoan t r ansmi t t ed by ph leboto in ine sandflies. The paras i te cycles between a nonmot i le , in t race l lu la r amast igote stage paras i t iz ing the mononuc lea r phagocytes of the mammal ian host and an extracel lular , moti le p romas t igo te stage in the insect vector, A s imilar p roma...
متن کاملMetabolic Variation during Development in Culture of Leishmania donovani Promastigotes
The genome sequencing of several Leishmania species has provided immense amounts of data and allowed the prediction of the metabolic pathways potentially operating. Subsequent genetic and proteomic studies have identified stage-specific proteins and putative virulence factors but many aspects of the metabolic adaptations of Leishmania remain to be elucidated. In this study, we have used an unta...
متن کاملMechanism of amphotericin B resistance in Leishmania donovani promastigotes.
Amphotericin B (AmB)-resistant Leishmania donovani promastigotes were selected by increasing drug pressure, and their biological features were compared with those of the wild-type parent strain. The 50% inhibitory concentration for resistant cells was 20 times higher than that for the wild-type. Resistance was stable after more than 40 passages in drug-free medium, and resistant promastigotes w...
متن کاملMiltefosine induces apoptosis-like death in Leishmania donovani promastigotes.
Miltefosine (hexadecylphosphocholine [HePC]) has proved to be a potent oral treatment for human visceral leishmaniasis due to Leishmania donovani. The molecular mechanisms that contribute to the antileishmanial activity of HePC are still unknown. We report that in wild-type promastigotes of Leishmania donovani HePC is able to induce a cell death process with numerous cytoplasmic, nuclear, and m...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1982
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.36.3.1023-1027.1982