OXA-35 is an OXA-10-related beta-lactamase from Pseudomonas aeruginosa
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چکیده
منابع مشابه
OXA-17, a further extended-spectrum variant of OXA-10 beta-lactamase, isolated from Pseudomonas aeruginosa.
Pseudomonas aeruginosa isolates 871 and 873 were isolated at Hacettepe University Hospital in Ankara and were highly resistant to ceftazidime (MIC, 128 microg/ml). Each produced three beta-lactamases, with pIs of 5.3, 6.1, and 7.9. The beta-lactamase with a pI of 5.3 was previously shown to be PER-1 enzyme. The antibiograms of the isolates were not entirely explained by production of PER-1 enzy...
متن کاملOXA-28, an extended-spectrum variant of OXA-10 beta-lactamase from Pseudomonas aeruginosa and its plasmid- and integron-located gene.
Pseudomonas aeruginosa ED-1, isolated from a pulmonary brush of a patient hospitalized in a suburb of Paris, France, was resistant to ceftazidime and of intermediate susceptibility to ureidopenicillins and to cefotaxime. Cloning and expression of the beta-lactamase gene content of this isolate in Escherichia coli DH10B identified a novel OXA-10 variant, OXA-28, with a pI value of 8.1 and a mole...
متن کاملOXA-18, a class D clavulanic acid-inhibited extended-spectrum beta-lactamase from Pseudomonas aeruginosa.
Clinical isolate Pseudomonas aeruginosa Mus showed resistance both to extended-spectrum cephalosporins and to aztreonam. We detected a typical double-disk synergy image when ceftazidime or aztreonam was placed next to a clavulanic acid disk on an agar plate. This resistance phenotype suggested the presence of an extended-spectrum beta-lactamase. Isoelectric focusing revealed that this strain pr...
متن کاملOXA-10 and OXA-2 ESBLs among multidrug-resistant Pseudomonas aeruginosa isolates from North West of Iran
Production of Extended spectrum β-lactamases (ESBLs) is a common mechanism of resistance in multidrug- Pseudomonas aeruginosa, but the frequency of different ESBLs may vary significantly in different parts of the world. The aim of this study was to investigate the prevalence of OXA-2/OXA-10 type ESBLs and class 1 integron among clinical isolates of P. aeruginosa in Ta...
متن کاملCrystal structure of the class D beta-lactamase OXA-10.
We report the crystal structure of a class D beta-lactamase, the broad spectrum enzyme OXA-10 from Pseudomonas aeruginosa at 2.0 A resolution. There are significant differences between the overall fold observed in this structure and those of the evolutionarily related class A and class C beta-lactamases. Furthermore, the structure suggests the unique, cation mediated formation of a homodimer. K...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2001
ISSN: 1460-2091
DOI: 10.1093/jac/48.5.717