Ovine panel reactive antibody assay of HLA responsivity to allograft bioengineered vascular scaffolds

Ovine panel reactive antibody assay of HLA responsivity to allograft bioengineered vascular scaffolds.

BACKGROUND Increasing evidence implicates immune response as a contributing factor in the failure of allograft valve transplants. Increases in panel reactive antibodies have been identified in human subjects. To correlate these responses with novel preimplantation processing methods to reduce cellularity, both a relevant panel reactive antibody assay and a chronic implantation animal model are ...

Application of Calculated Panel Reactive Antibody Using HLA Frequencies in Koreans

BACKGROUND Introduction of the Luminex panel reactive antibody (PRA)-single antigen (SA) assay has increased the detection rates of unacceptable antigens in sensitized patients; the calculated PRA (CPRA) level represents the percentage of actual organ donors that express 1 or more of these unacceptable antigens. We developed a CPRA calculator based on the HLA frequencies in Koreans to measure s...

Bioengineered Scaffolds for Peripheral Nerve Regeneration

Assessment of Spanish Panel Reactive Antibody Calculator and Potential Usefulness

BACKGROUND AND OBJECTIVES The calculated panel reactive of antibodies (cPRAs) necessary for kidney donor-pair exchange and highly sensitized programs are estimated using different panel reactive antibody (PRA) calculators based on big enough samples in Eurotransplant (EUTR), United Network for Organ Sharing (UNOS), and Canadian Transplant Registry (CTR) websites. However, those calculators can ...

Acute antibody-mediated renal allograft rejection associated with HLA-Cw17 antibody

Detection of donor-specific human leukocyte antigen (HLA) antibodies is an important part of diagnosis of antibody-mediated rejection (AMR) in the renal transplant population. Donor-specific antibodies (DSA) against HLA-C, a Class 1 major histocompatibility gene product, are not considered to be of major importance in renal transplant rejection. Typing for HLA-C is not a routine part of pre- an...