Overview of the advantages and disadvantages of chimeric antigen receptor T cell therapy in the tumor microenvironment

T cells genetically modified to express a receptor that identifies specific antigen, known as chimeric antigen (CAR) cells, have led advancements in the treatment of hematological malignancies and tumor microenvironment. CAR-T target origin tumors on vascular side inflammatory cytokines where microenvironment forms block immunosuppressive checkpoints. The efficacy cell remains controversial because its toxicity damages organ structures, including neurological, pulmonary, cardiac, muscular causes fatal abnormality. In this review, we discuss advantages disadvantages immunotherapy