OVERVIEW OF MUCOADHESIVE BIOPOLYMERS FOR BUCCAL DRUG DELIVERY SYSTEMS
نویسندگان
چکیده
منابع مشابه
A clinical perspective on mucoadhesive buccal drug delivery systems
Mucoadhesion can be defined as a state in which two components, of which one is of biological origin, are held together for extended periods of time by the help of interfacial forces. Among the various transmucosal routes, buccal mucosa has excellent accessibility and relatively immobile mucosa, hence suitable for administration of retentive dosage form. The objective of this paper is to review...
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Among novel drug delivery systems, Buccal mucoadhesive systems have attracted great attention in recent years due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. Mucoadhesion may be defined as the process where polymers attach to biological substrate or a synthetic or natural macromolecule, to mucus or an epithelial surface. Buccal mucoadhes...
متن کاملMucoadhesive drug delivery systems
Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diff...
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Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which have maximum absorption in gastrointestinal tract (GIT) require increased duration of stay in GIT. Thus, mucoadhesive dosage forms are advantage...
متن کاملIn-vitro and In-vivo Evaluation of Novel Mucoadhesive Buccal Drug Delivery Systems-a Review
The buccal mucosa is one of the administration sites that might provide an alternative for peroral administration. Mucoadhesive buccal drug delivery systems is one of the most important novel drug delivery systems with its various advantages and it has a lot of potential in formulating dosage forms for various chronic diseases. The delivery of drugs through the buccal mucosa has attracted much ...
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ژورنال
عنوان ژورنال: International Journal of Applied Pharmaceutics
سال: 2019
ISSN: 0975-7058
DOI: 10.22159/ijap.2019v11i6.35438