Overview of Gene Expression Analysis in Gastric Disease Infected with Helicobacter pylori: CLDN1 and MMP9 Could Be Biomarkers for Early Diagnosis of Gastric Cancer
نویسندگان
چکیده
Chronic Helicobacter pylori infection produces several lesions in the human stomach, which can progress to chronic atrophic gastritis and gastric cancer. To date, there is very little information on gene expression its relationship with progression In this study, we performed a analysis during order identify possible biomarkers that allow an early diagnosis of We studied biopsies from patients The were analyzed by microarray corroborated qPCR validated through immunohistochemistry. Our results revealed profiles showed molecular changes mucosa, leading CLDN1, CLDN7, OLFM4, C-MYC MMP9 more notable gastritis. patterns observed study allowed identification CLDN1 proteins as promising stages cancer development.
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ژورنال
عنوان ژورنال: Processes
سال: 2022
ISSN: ['2227-9717']
DOI: https://doi.org/10.3390/pr10020196