Overexpression of miR-22 attenuates oxidative stress injury in diabetic cardiomyopathy via Sirt 1
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چکیده
منابع مشابه
Diosgenin attenuates cardiac oxidative stress in streptozotocin- induced diabetic rat
Background and Objective: Chronic diabetes mellitus (DM) leads to cardiovascular dysfunction. Diosgenin is a natural steroidal saponin with cardiovascular protective potential. In this research study, the beneficial effect of diosgenin was evaluated on some markers of oxidative stress in cardia tissue of streptozotocin (STZ)-diabetic rats. Materials and Methods: Male Wistar rats (n = 28) were ...
متن کاملIGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress.
Stimulation of the local renin-angiotensin system and apoptosis characterize the diabetic heart. Because IGF-1 reduces angiotensin (Ang) II and apoptosis, we tested whether streptozotocin-induced diabetic cardiomyopathy was attenuated in IGF-1 transgenic mice (TGM). Diabetes progressively depressed ventricular performance in wild-type mice (WTM) but had no hemodynamic effect on TGM. Myocyte apo...
متن کاملEnalapril attenuates oxidative stress in diabetic rats.
Oxidative stress is involved in both the pathogenesis and complications of diabetes. ACE inhibitors can slow the progression of cardiac and renal impairments related to diabetes. The effect of enalapril treatment on oxidative stress and tissue injury was studied in hearts, kidneys, and livers from streptozotocin-induced diabetic rats. Twenty-four rats were divided into the following groups: str...
متن کاملCannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory and cell death signaling pathways in diabetic cardiomyopathy
Objectives—In this study, we have investigated the effects of cannabidiol (CBD) on myocardial dysfunction, inflammation, oxidative/nitrosative stress, cell death and interrelated signaling pathways, using a mouse model of type I diabetic cardiomyopathy and primary human cardiomyocytes exposed to high glucose. Background—CBD, the most abundant nonpsychoactive constituent of Cannabis sativa (mari...
متن کاملdiosgenin attenuates cardiac oxidative stress in streptozotocin- induced diabetic rat
background and objective: chronic diabetes mellitus (dm) leads to cardiovascular dysfunction. diosgenin is a natural steroidal saponin with cardiovascular protective potential. in this research study, the beneficial effect of diosgenin was evaluated on some markers of oxidative stress in cardia tissue of streptozotocin (stz)-diabetic rats. materials and methods: male wistar rats (n = 28) were d...
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ژورنال
عنوان ژورنال: Cardiovascular Therapeutics
سال: 2018
ISSN: 1755-5914
DOI: 10.1111/1755-5922.12318