Overcoming the Current Challenges of Thiamine Deficiency Disorders (P10-091-19)

Thiamine Deficiency in Organic

Since cocarboxylase, derived from thiamine, is necessary for normal utilization of pyruvate by heart muscle, the importance of adequate body stores of thiamine in patients with chronic heart disease is quite obvious. In order to investigate the occurrence of subclinical thiamine deficiency in patients with chronic heart disease, the thiamine was determined in the four-hour specimen of urine aft...

Prolonged Human Thiamine Deficiency

Eight clinically proved cases of prolonged thiamine deficiency were evaluated by routine pathologic study. The msieroseopic features were evaluated by comparison with sections of myocardiuni obtained from nornmal individuals and individuals suffering from cardiac diseases of other varieties. No specific transitory or permanent alterations were demonstrable. It is concluded that beriberi heart d...

Neurocirculatory Manifestations of Thiamine Deficiency

The diagnosis of thiamine deficiency is essentially made on clinical grounds and may present with neurological deficit such as peripheral neuropathy and Wernicke’s encephalopathy, or with high output heart failure (wet beriberi). This study was done to determine the frequency with which both the neurological and cardiovascular manifestations coexist in states of thiamine deficiency. The hospita...

Effects of thiamine deficiency and thiamine administration on the thiamine diphosphate-dependent enzymes in rat liver.

The activities of pyruvate and 2-oxoglutarate dehydrogenases were determined by a spectrophotometric method according to Massey, that of transketolase deter mined by Racker's method. The values of enzyme activity as well as the thiamine contents in the preparations were compared with those of the animals whose deficiencies were restored by thiamine administration. The thiamine deprivation resul...

Electrocardiogram of the month. Possible thiamine deficiency.