Over-expression of the c-myc proto-oncogene in colorectal carcinoma
نویسندگان
چکیده
منابع مشابه
The protein encoded by the human proto-oncogene c-myc.
The proto-oncogene c-myc may play a role in controlling the growth and division of normal cells, and abnormalities of the gene have been implicated in the genesis of a substantial variety of human tumors. To facilitate further study of these issues, we developed antisera that permit the identification and isolation of the protein encoded by the human and other mammalian versions of c-myc. We fo...
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The results of recent studies on the molecular biology of cancer suggest the abnormal expression of cellular proto-oncogenes in the process of carcinogenesis [1]. The activation of proto-oncogenes, i.e., their conversion into cellular oncogenes, is associated with gene structural alterations and mutations resulting in the unregulated production of oncoproteins, matched by deranged biological fu...
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The steady state levels of c-myc mRNA have been measured in RNA samples extracted from colonoscopic biopsies of inflammatory bowel disease patients obtained at routine endoscopy sessions. Biopsies were immediately frozen in liquid nitrogen limiting the ischaemic time to less than 15 seconds, and can be stored for up to 96 hours before separation of RNA. Yields of RNA using biopsies were 0.137 (...
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The aim of the study was to assess the expression and clinical significance of C-myc proto-oncogene in the progression of cervical neoplasms. To establish the role of this proto-oncogene in uterine cervix carcinogenesis, we examined 69 tissue samples of: low grade cervical squamous intraepithelial lesions (SIL) (n=16), high grade SIL (n=11), portio vaginalis uteri (PVU) carcinoma in situ (n=11)...
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The c-ret proto-oncogene encodes a receptor tyrosine kinase whose normal function has yet to be determined. To begin to investigate the potential role of this gene in vertebrate development, we have isolated cDNA clones representing the murine c-ret gene, and have analyzed the pattern of expression during mouse embryogenesis, using northern blotting, in situ hybridization to histological sectio...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1993
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1993.350