Outer Mitochondrial Membrane Localization of Apoptosis-Inducing Factor: Mechanistic Implications for Release
نویسندگان
چکیده
منابع مشابه
Outer mitochondrial membrane localization of apoptosis-inducing factor: mechanistic implications for release
Poly(ADP-ribose) polymerase-1-dependent cell death (known as parthanatos) plays a pivotal role in many clinically important events including ischaemia/reperfusion injury and glutamate excitotoxicity. A recent study by us has shown that uncleaved AIF (apoptosis-inducing factor), but not calpain-hydrolysed truncated-AIF, was rapidly released from the mitochondria during parthanatos, implicating a...
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ژورنال
عنوان ژورنال: ASN Neuro
سال: 2009
ISSN: 1759-0914,1759-0914
DOI: 10.1042/an20090046