منابع مشابه
Power Efficiency of Outer Hair Cell Somatic Electromotility
Cochlear outer hair cells (OHCs) are fast biological motors that serve to enhance the vibration of the organ of Corti and increase the sensitivity of the inner ear to sound. Exactly how OHCs produce useful mechanical power at auditory frequencies, given their intrinsic biophysical properties, has been a subject of considerable debate. To address this we formulated a mathematical model of the OH...
متن کاملMolecular motor and electrokinetic contributions to outer hair cell electromotility.
The outer hair cell of the inner ear is believed to be responsible for the high sensitivity and selectivity of mammalian hearing. Molecular motors are generally believed to cause the electrically-driven length change (electromotility) of the outer hair cell. It has been suggested that electrokinetic effects might also play a significant role in electromotility, along with the molecular motors. ...
متن کاملAcetylcholine, outer hair cell electromotility, and the cochlear amplifier.
The dominant efferent innervation of the cochlea terminates on outer hair cells (OHCs), with acetylcholine (ACh) being its principal neurotransmitter. OHCs respond with a somatic shape change to alterations in their membrane potential, and this electromotile response is believed to provide mechanical feedback to the basilar membrane. We examine the effects of ACh on electromotile responses in i...
متن کاملSimulation of motor-driven cochlear outer hair cell electromotility.
We propose a three-dimensional (3D) model to simulate outer hair cell electromotility. In our model, the major components of the composite cell wall are explicitly represented. We simulate the activity of the particles/motor complexes in the plasma membrane by generating active strains inside them and compute the overall response of the cell. We also consider the constrained wall and compute th...
متن کاملA membrane bending model of outer hair cell electromotility.
We propose a new mechanism for outer hair cell electromotility based on electrically induced localized changes in the curvature of the plasma membrane (flexoelectricity). Electromechanical coupling in the cell's lateral wall is modeled in terms of linear constitutive equations for a flexoelectric membrane and then extended to nonlinear coupling based on the Langevin function. The Langevin funct...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine
سال: 2018
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a033522