Outcomes and Mortality of Grade 1 Ascites and Recurrent Ascites in Patients With Cirrhosis

Background & AimsAscites has been classified according to quantity and response medical therapy. Despite its precise definitions, little is known about the effects of grade 1 ascites or recurrent (i.e. that recurs at least on 3 occasions within a 12-month period despite dietary sodium restriction adequate diuretic dosage) patient outcome. We studied progression in large cohort outpatients with cirrhosis.MethodsWe performed post-hoc analysis data from 547 cirrhosis (259 without ascites, 54 patients 234 2 ascites) who participated care management program study Italy March 2003 through September 2017. collected demographic, clinical, laboratory were evaluated every 6 months. Patients received abdominal ultrasound inclusion twice year. Number volume paracentesis collected, when available. followed until death, liver transplantation, 2018. The median follow-up time was 29 Primary outcomes mortality development complications cirrhosis.ResultsThere no significant difference 60-month transplant-free survival between vs (36% 43%) but significantly lower both groups compared (68%; P < .001 for comparisons). However, systemic inflammation rate greater than ascites. Development did not differ (10% 14%). There 36-month responsive treatment (78% 62%), whereas refractory had (23%; P<.001; = .022).ConclusionsIn an cirrhosis, we found associated inflammation, more complications, increased Mortality does treatment. Ascites cirrhosis. .022). In