منابع مشابه
Endogenous ouabain is not ouabain.
T he concept of a circulating digitalis-like inhibitor of the sodium pump, Na + , K +-ATPase, evolved from studies performed in the 1960s. De Wardener et al 1 addressed the question of whether a small increase in the glomerular filtration rate together with changes in the concentration of the more recently discovered hormone aldosterone could explain the natriuresis that generally followed salt...
متن کاملRadioimmunoassays, ouabain-like material, and ouabain.
Radioimmunoassays, Ouabain-Like Material, and Ouabain To the Editor: We read with interest the article by Bauer et al1 on the changes in the plasma concentration of a ouabain-like compound associated with vigorous exercise in both humans and dogs. The authors comment on the result that is most striking to us, namely the remarkably high concentrations of the immunoassayable substance achieved wi...
متن کاملEndogenous Ouabain
In this brief article, we summarize recent reports about endogenous ouabain (EO), a cardiotonic steroid hormone. This includes analysis of mammalian EO, the discovery of EO isomers, regulation of intracellular signaling by EO, and the roles of EO in hypertension, pregnancy, and heart and kidney diseases. Novel ouabain-resistant mice that elucidate the key roles of α2 Na pumps and their cardioto...
متن کاملEffects of Ouabain
SUMNIARY XMyocardial electrolyte balance and hemodynamics were studied in 14 patients before and after the administration of ouabain. The drug caused a significant loss of potassium from the myocardium. This was accompanied by a significant positive inotropic response, indicated by an increase in the rate of rise of left ventricular pressure and systolic ejection-rate index. Heart rate, cardiac...
متن کاملEffects of Ouabain
The effects of intravenous ouabain (0.015 mg/kg body weight) were assessed in 13 patients 3-5 weeks after an uncomplicated acute myocardial infarction. The patients were not in clinical cardiac failure and were not having anginal pain. The mean + SEM of the values prior to (C) and 1 hour after ouabain (A) were: left ventricular end-diastolic pressure (LVEDP), C 18.6 ± 1.5, A 10.2 + 1.4; stroke ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1936
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)74799-6