OTX2 Represses Myogenic and Neuronal Differentiation in Medulloblastoma Cells
نویسندگان
چکیده
منابع مشابه
OTX2 represses myogenic and neuronal differentiation in medulloblastoma cells.
The brain development transcription factor OTX2 is overexpressed and/or genomically amplified in most medulloblastomas, but the mechanistic basis for its contributions in this setting are not understood. In this study, we identified OTX2 as a transcriptional repressor and a gatekeeper of myogenic and neuronal differentiation in medulloblastoma cells. OTX2 binds to the MyoD1 core enhancer throug...
متن کاملTumor and Stem Cell Biology OTX2 Represses Myogenic and Neuronal Differentiation in Medulloblastoma Cells
The brain development transcription factor OTX2 is overexpressed and/or genomically amplified in most medulloblastomas, but the mechanistic basis for its contributions in this setting are not understood. In this study, we identified OTX2 as a transcriptional repressor and a gatekeeper of myogenic and neuronal differentiation in medulloblastoma cells. OTX2 binds to the MyoD1 core enhancer throug...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2012
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-12-0614