OTHR-08. MULTIDISCIPLINARY APPROACH TO PAEDIATRIC BRAIN CANCER BIO-BANKING IMPROVES ENROLLMENT, FACILITATES DISCOVERY RESEARCH, AND ENABLES BETTER ACCESS TO DIAGNOSTIC AND THERAPEUTIC STUDIES

Abstract Despite the significant progress made in multi-modal treatment of childhood malignancies over last four decades with a concomitantly increased cure rates, benefit is still largely limited to patients leukemias, lymphomas and localized non-CNS solid tumors, leaving high-risk tumours most CNS minimal advancements. More research critical understand what drives these cancers investigate best ways deliver curative therapies. Translational relies on patient-derived tissue samples, animal models cell-cultures biological, genetic, molecular mechanisms disease. To facilitate patient care outcomes it becoming increasingly important that paediatric clinical trials include availability as part eligibility criteria, making collection storage mandate personalized medicine pillar modern cancer medicine. Monash Children’s Cancer Biobank was established 2011. Since 2017, total 64 were diagnosed across all grades, an overall 69% patients’ tissues being bio-banked at time initial diagnosis. Through combination educational forum, regular multi-disciplinary meetings, early involvement medical oncology biobank staff, our neurosurgical pathology colleagues, management planning, acquisition for bio-banking from 44% 82% course 5 years. This consequently led 100% enrollment tissue-enabling studies allowing banking both fresh-frozen living cell-line models, facilitating discovery efforts Victorian Paediatric Consortium’s analysis pipeline (https://vicpcc.org.au/dashboard). significantly improves opportunities identification targetable pathways, access targeted therapies, onto predisposition syndromes.