منابع مشابه
Hypophosphatemic rickets and osteomalacia.
The hypophosphatemic conditions that interfere in bone mineralization comprise many hereditary or acquired diseases, all of them sharing the same pathophysiologic mechanism: reduction in the phosphate reabsorption by the renal tubuli. This process leads to chronic hyperphosphaturia and hypophosphatemia, associated with inappropriately normal or low levels of calcitriol, causing osteomalacia or ...
متن کامل199 - Osteomalacia and rickets*
1997 Vitamin D is converted in the liver by a vitamin D-25-hydroxylase (25-OHase) to form the major circulating form of vitamin D, 25-hydroxyvitamin D [25(OH)D]. There have been at least four different 25-OHases identified both in mitochrondia and in microsomes. 25(OH)D is, however, biologically inert and requires hydroxylation in the kidneys on carbon 1 by the CYP27B mitrochondrial enzyme 25-h...
متن کاملRickets and osteomalacia
Although the relationship between rickets and vitamin D was recognized over 60 years ago it is only relatively recently that the metabolic pathway leading to the active form of vitamin D was recognized. We now understand that vitamin D in the form of one of its active metabolites is necessary for the maintenance of calcium homeostasis and we appreciate in part the mechanisms by which this is br...
متن کاملOncogenic osteomalacia
Severe osteomalacia (confirmed by the examination of thin undecalcified bone biopsy sections) associated with hypophosphataemia developed in a 60 year old woman. A skeletal x-ray survey showed a lytic lesion in the right proximal femur, and this was curetted, showing a vascular tumour. The patient's symptoms improved almost immediately and serum phosphate concentrations returned to normal. Some...
متن کاملOncogenic osteomalacia.
Severe osteomalacia (confirmed by the examination of thin undecalcified bone biopsy sections) associated with hypophosphataemia developed in a 60 year old woman. A skeletal x-ray survey showed a lytic lesion in the right proximal femur, and this was curetted, showing a vascular tumour. The patient's symptoms improved almost immediately and serum phosphate concentrations returned to normal. Some...
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ژورنال
عنوان ژورنال: QJM: An International Journal of Medicine
سال: 2018
ISSN: 1460-2725,1460-2393
DOI: 10.1093/qjmed/hcy293