Osteointegration of polylactide-based implants

Background. Materials degrading after implantation into bone are in the field of actual vision orthopediс surgeon. These materials include polylactides, which ideal material for creating implants 3D-printer, especially complex shapes and different sizes. The purpose study is to conduct a comparative analysis remodeling under conditions polylactide 3D-printed screws metadiaphyseal diaphyseal defects rat femur. methods. Comparative Ingeo™ Biopolymer 4032D femur 15, 30, 90, 180 270 days conducted. After polylactide, areas with were examined by histological method determination osteointegration index. Results. It was found that all periods kept their shape, surrounded tissue. osseointegration index on 270th day 97.1 94.3 %, respectively, statistically higher compared 15th 2.2 2.3 times (p < 0.001). Conclusions. polylactide-based biocompatible, have high qualities, do not cause inflammation surrounding soft tissues marrow, lead destructive changes sites. At end (270 days), degradation found, makes it possible use fixation or filling cavities compact spongy bones long time.