Osteoarthritis disease progression through the lower extremity: A review

It has long been felt that osteoarthritis is the result of wear and tear. Many physicians are not aware biological science now validated this increased “wear tear” on joint loading-induced stresses undermine cell function aging. The loading creates shear forces cartilage leads to oxidants. These oxidants then cause chondrocyte premature aging, leading development what we know as osteoarthritis.
 Studies have also found a significant association between foot pain knee hip pain. Likewise, many relationship hip, kinetic chain. chain being dynamic transfer during ambulation foot, ankle, knee, hip. explains how body’s joints segments affect one another movement, so play role in results from transferred mechanical stress another. same This article involves literature connection lower limb highlights need consider related when addressing injury address perhaps delay progression joints.