منابع مشابه
Op-cbio140913 1521..1525
Motivation: Machine learning may be the most popular computational tool in molecular biology. Providing sustained performance estimates is challenging. The standard cross-validation protocols usually fail in biology. Park and Marcotte found that even refined protocols fail for protein–protein interactions (PPIs). Results: Here, we sketch additional problems for the prediction of PPIs from seque...
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We report the fabrication of a three dimensional branched ZnO/Si heterojunction nanowire array by a two-step, wafer-scale, low-cost, solution etching/growth method and its use as photoelectrode in a photoelectrochemical cell for high efficiency solar powered water splitting. Specifically, we demonstrate that the branched nanowire heterojunction photoelectrode offers improved light absorption, i...
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The purpose of this study was to evaluate the impact of intestinal efflux transporters on the in vivo oral absorption process. Three model drugs—fexofenadine (FEX), sulfasalazine (SASP), and topotecan (TPT)—were selected as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and P-gp and BCRP substrates, respectively. The drugs were orally administered to portal vein– cannulated rat...
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1521 The Rockefeller University Press $30.00 J. Cell Biol. Vol. 216 No. 6 1521–1523 https://doi.org/10.1083/jcb.201704114 Caspase-2 is a critical component of the cellular machinery designed to remove damaged cells, preventing disease. Consistent with a function in the apoptosis pathway, caspase-2, like caspase-3, is a tumor suppressor (Puccini et al., 2013). Although caspase-2 is required to i...
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Information on the intestinal microbiota has increased exponentially this century because of technical advancements in genomics and metabolomics. Although information on the synthesis of bile acids by the liver and their transformation to secondary bile acids by the intestinal microbiota was the first example of the importance of the intestinal microbiota in biotransforming chemicals, this revi...
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ژورنال
عنوان ژورنال: OTAM(Ankara
سال: 2017
ISSN: 1019-469X
DOI: 10.1501/otam_0000000718