Oseltamivir in human avian influenza infection

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Oseltamivir in human avian influenza infection

Avian influenza A viruses continue to cause disease outbreaks in humans, and extrapulmonary infection is characteristic. In vitro studies demonstrate the activity of oseltamivir against avian viruses of the H5, H7 and H9 subtypes. In animal models of lethal infection, oseltamivir treatment and prophylaxis limit viral replication and improve survival. Outcomes are influenced by the virulence of ...

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The Southeast Asian outbreak of the highly lethal avian influenza A H5N1 infection in humans is unlikely to abate because of the enormous number of backyard farms providing poultry as the main source of food protein in developing countries. This increases the risk of the emergence of a reassortant pandemic influenza virus with improved human-to-human transmissibility. Currently triage of suspec...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2010

ISSN: 0305-7453,1460-2091

DOI: 10.1093/jac/dkq013