Orphan receptor and chaperon functions of sigma-1 receptor
نویسندگان
چکیده
منابع مشابه
An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ
The estrogen receptor-related receptor gamma (ERRgamma/ERR3/NR3B3) is a member of the nuclear receptor superfamily that activates transcription in the absence of ligand. However, the detailed mechanism of gene regulation by ERRgamma is not fully understood. In this study we have found that the orphan nuclear receptor ERRgamma activates the DAX-1 promoter, which, in turn, represses transactivati...
متن کاملBiochemical Pharmacology of the Sigma-1 Receptor.
The sigma-1 receptor (S1R) is a 223 amino acid two transmembrane (TM) pass protein. It is a non-ATP-binding nonglycosylated ligand-regulated molecular chaperone of unknown three-dimensional structure. The S1R is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membranes with broad functions that regulate cellular calcium homeostasis and reduce oxidative stress. S...
متن کاملFocus on molecules: the Sigma-1 receptor.
The Sigma-1 receptor (accession number NP 005857) has no known homology with other receptors and in fact most closely resembles a C-8,7 sterol isomerase found in fungi (Hayashi and Su, 2003). The gene encodes a protein consisting of 223 amino acids with two transmembrane spanning domains and a typical argenine-argenine (R–R) endoplasmic reticulum (ER) locating signal near the N terminal end. Th...
متن کاملThe orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).
Regulation of gene transcription is controlled in part by nuclear receptors that function coordinately with coregulator proteins. The human constitutive androstane receptor (CAR; NR1I3) is expressed primarily in liver and regulates the expression of genes involved in xenobiotic metabolism as well as hormone, energy, and lipid homeostasis. In this report, DAX-1, a nuclear receptor family member ...
متن کاملThe orphan nuclear receptor, DAX-1, functions as a potent co-repressor of the constitutive androstane receptor (CAR, NR1I3)
Regulation of gene transcription is controlled in part by nuclear receptors (NR) that function coordinately with coregulator proteins. The human constitutive androstane receptor (CAR; NR1I3) is primarily expressed in liver and regulates the expression of genes involved in xenobiotic metabolism as well as hormone, energy and lipid homeostasis. In this report, DAX-1, a NR family member with corep...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2014
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.143.263