Orolingual angioedema treated with Icatibant post-thrombolysis for ischaemic stroke

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Orolingual and abdominal angioedema post thrombolysis and thrombectomy.

A 53-year-old man treated with an angiotensin-converting enzyme (ACE) inhibitor presented with left hemiplegia (NIH Stroke Scale 23). Magnetic resonance angiography revealed a right proximal middle cerebral artery occlusion (figure 1). Thirty minutes after thrombolysis, orolingual swelling was observed. Two hours later, just after mechanical thrombectomy was completed, he developed painful abdo...

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Orolingual Angioedema During or After Thrombolysis for Cerebral Ischemia.

BACKGROUND AND PURPOSE Orolingual angioedema (OLAE) is a life-threatening complication of intravenous thrombolysis. Our objective was to compare outcomes of patients with and without OLAE. METHODS We prospectively included consecutive patients who received intravenous thrombolysis for cerebral ischemia at Lille University Hospital. We examined tongue and lips every 15 minutes during thromboly...

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Raising awareness of orolingual angioedema as a complication of thrombolysis in acute stroke patients.

1 Sundt TM, Sharbrough FW, Piepgras DG, Kearns TP, Messick JM, O’Fallon WM: Correlation of cerebral blood flow and electroencephalographic changes during carotid endarterectomy. Mayo Clin Proc 1981; 56: 533–543. 2 van Mook W, Rennenberg R, Schurink G, et al: Cerebral hyperperfusion syndrome. Lancet Neurol 2005; 4: 877–888. 3 Russell DA, Gough MJ: Intracerebral haemorrhage following carotid enda...

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Hemi Orolingual Angioedema after tPA Administration for Acute Ischemic Stroke

INTRODUCTION As studies continue to demonstrate the efficacy of intravenous tissue plasminogen activator (tPA) in acute ischemic stroke, the exclusion criteria continue to narrow, and the time-window continues to increase.1-3 The most dreaded adverse effect of tPA, hemorrhagic conversion of an ischemic stroke, is well known and well published.3 However, as an increasing number of patients are r...

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Thrombolysis for acute ischaemic stroke.

BACKGROUND Most strokes are due to blockage of an artery in the brain by a blood clot. Prompt treatment with thrombolytic drugs can restore blood flow before major brain damage has occurred and improve recovery after stroke in some people. Thrombolytic drugs, however, can also cause serious bleeding in the brain, which can be fatal. One drug, recombinant tissue plasminogen activator (rt-PA), is...

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ژورنال

عنوان ژورنال: Journal of Clinical Neuroscience

سال: 2018

ISSN: 0967-5868

DOI: 10.1016/j.jocn.2017.12.003