Ornithine Aminotransferase versus GABA Aminotransferase: Implications for the Design of New Anticancer Drugs
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چکیده
منابع مشابه
Ornithine ketoacid aminotransferase in the bovine eye.
Ornithine ketoacid aminotransferase in bovine ocular tissues was studied biochemically. The retinal pigment epithelium, ciliary body, iris, and neuroretina showed high specific activity. The cornea and choroid revealed a lower activity. Aqueous humor, lens, vitreous body, and sclera showed no activity. The pH optima of the enzyme in the retinal pigment epithelium and ciliary body were near 8.0.
متن کاملTranscriptional analysis of the human ornithine aminotransferase promoter.
The regulation of ornithine delta-aminotransferase (OAT) expression is poorly characterized in humans, but in rat there are tissue-specific responses to nutritional and hormonal stimuli. We analyzed 1.3 kilobases of 5'-flanking sequence and part of intron 1 of the human OAT gene and found several candidate regulatory sequences including four copies of a motif also present in the promoters of th...
متن کاملSex-differential expression of ornithine aminotransferase in the mouse kidney.
The mouse kidney expresses the gene of ornithine aminotransferase (Oat). Previous works suggest that Oat is differentially expressed in female and male mouse kidney (Alonso E, Rubio V. Biochem J 259: 131-138, 1989; Levillain O, Diaz JJ, Blanchard O, Dechaud H. Endocrinology 146: 950-959, 2005; Manteuffel-Cymborowska M, Chmurzynska W, Peska M, Grzelakowska-Sztabert B. Int J Biochem Cell Biol 27:...
متن کاملA deletion in the ornithine aminotransferase gene in gyrate atrophy.
Gyrate atrophy (GA) is an autosomal recessive chorioretinal degenerative disease of the eye caused by an inborn defect of the nuclear encoded mitochondrial enzyme ornithine aminotransferase (OAT). We have described previously a GA patient with a 5.0-kilobase pair truncated EcoRI OAT gene fragment and the absence of OAT mRNA on Northern blot analysis. Cloning and sequencing analysis of the trunc...
متن کاملExpression defect of ornithine aminotransferase gene in gyrate atrophy.
A generalized deficiency in the mitochondrial enzyme, ornithine aminotransferase (OAT: EC 2.6.1.13), is the hallmark of gyrate atrophy (GA), a hereditary degenerative disease of the choroid and retina of the eye that leads to blindness. A human OAT cDNA, previously constructed and characterized in our laboratory, and anti-human OAT antibody were used as probes to examine the OAT gene, mRNA and ...
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ژورنال
عنوان ژورنال: Medicinal Research Reviews
سال: 2014
ISSN: 0198-6325
DOI: 10.1002/med.21328